Hlavní Stránka Česká Verze

Profil: Expert v oboru orgánů na čipech, mikrofluidických systémů a mikrovýroby se 17-ti letou pracovní zkušeností  na  Massachusetts Institute of Technology  & Harvard University, USA a čtyřletou funkcí  jako ředitel vývoje hardweru v jedné nejuspešnější firem na světě zaměřených na orgány na čipech  Mimetas, Nizozemsko

Technická  a vědecká  specializace:

• • návrh nových koncepců a designů

  • mikrofluidické systémy

  • mikrofyziologické  systémy na pěstovani bunek/orgány na čipech

  • návrh "higher throughput" mikrofluidických systémů vhodných pro robotické ovládání 

  • 3CAD design (SolidWorks)

  • polymery pro výrobu mikrofluidických systémů

  • rapid prototyping

  • mikrovýrobní technologie/masová  výroba mikrosoučástek

Technical and scientific expertise:

• new concept development and design

• microfluidics

• microphysiological cell culture systems/organs-on-chips

• design of higher throughput microfluidic systems amenable to robotic fluid handling

• 3D CAD design

• polymer materials for production of microfluidic systems

• rapid prototyping

• microfabrication and microdevice mass production

Vybrané publikace:

• G. Rabussier , I. Bünter , J. Bouwhuis , C. Soragni , T. van Zijp , C. P. Ng , K. Domansky , L. J. de Windt , P. Vulto , C. E. Murdoch , K. M. Bircsak , H. L. Lanz, Healthy and diseased placental barrier on-a-chip models suitable for standardized studies, Acta Biomater, 2023 Apr 26; S1742-7061(23)00232-5. doi: 10.1016/j.actbio.2023.04.033

• F. Bonanini , D. Kurek , S. Previdi , A. Nicolas , D. Hendriks , S. de Ruiter , M. Meyer , M. Clapés Cabrer , R. Dinkelberg , S. Bonilla García , B. Kramer, T. Olivier , H. Hu , C. López-Iglesias , F. Schavemaker,  E. Walinga , D. Dutta , K. Queiroz , K. Domansky , B. Ronden , J. Joore , H. L Lanz , P. J. Peters , S. J. Trietsch , H. Clevers , P. Vulto,  In vitro grafting of hepatic spheroids and organoids on a microfluidic vascular bed, Angiogenesis, 2022 Nov;25(4): 455-470. doi: 10.1007/s10456-022-09842-9. Epub 2022 Jun 15

• A. Nicolas,   F. Schavemaker,   K. Kosim,   D. Kurek,   M. Haarmans,   M. Bulst,  K. Lee,   S. Wegner,   T. Hankemeier,    J. Joore,   K. Domansky,   H. L. Lanz,   P. Vulto  and  S. J. Trietsch, High-throughput transepithelial electrical resistance (TEER) measurements on perfused membrane-free epithelia, Lab Chip, 2021, 21, 1676-1685, DOI: 10.1039/D0LC00770F

• K. Domansky et al., SEBS elastomers for fabrication of microfluidic devices with reduced drug absorption by injection molding and extrusion, Microfluidics and Nanofluidics, 2017 June 08; 21:107, doi:10.1007/s10404-017-1941-4. [pdf]

• J. H. Kang, M. Super, C. W. Yung, R. M. Cooper, K. Domansky, A. Graveline, T. Mammoto, J. B. Berthet, H. Tobin, M. Cartwright, A. Watters, M. Rottman, A. Waterhouse, K. Mammoto, N. Gamini, M. Rodas, A. Kole, A. Jiang, T. M. Valentin, A. Diaz, D. E. Ingber, An extracorporeal blood cleansing device for sepsis therapy, Nature Medicine, 2014, 10, 1211 - 1216.

• R. M. Cooper, D. C. Leslie, K. Domansky, A. Jain, M. Super, C. Yung, M. Cho, S. Workman, and D. E. Ingber, A microdevice for rapid optical detection of magnetically captured rare blood pathogens, Lab Chip, 2014, 14, 182-188. [pdf]

• K. Domansky, D. C. Leslie, J. P. Fraser, J. McKinney, J. P. Fraser, J. D. Sliz, T. Hamkins-Indik, G. A. Hamilton, A. Bahinski, and D. E. Ingber, Clear castable polyurethane elastomer for fabrication of microfluidic device, Lab Chip, 2013, 13, 3956-3964. [pdf]

• K. Domansky, M. Karpelson, R. J. Wood, and D. E. Ingber, On-chip aerosol generation for organs-on-chips, Proceedings of the 16th International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS), Okinawa, Japan, October 28–November 1, 2012, 302–304. [pdf]

• K. Domansky, W. Inman, J. Serdy, A. Dash, M. H. M. Lim, L. G. Griffith, Perfused Multiwell Plate for 3D Liver Tissue Engineering, Lab Chip, 2010, 10, 51-58. [pdf]

• W. Inman, K. Domansky, J. Serdy, B. Owens, D. Trumper, and L. G. Griffith, Design, Modeling and Fabrication of a Constant Flow Pneumatic Micropump, J. Micromech. Microeng. , 2007, 17, 891-899. [pdf]

• K. Domansky, A. Sivaraman, and L. G. Griffith, Micromachined bioreactor for in vitro cell self-assembly and 3D tissue formation, Lab-on-Chips for Cellomics: Micro and Nanotechnologies for Life Science, edited by Helene Andersson and Albert van den Berg, Kluwer Academic Publishers, 2004, pp. 319 – 346 (book chapter). [pdf]

• M. J. Powers, K. Domansky, M. R. Kaazempur-Mofrad, A. Kalezi, A. Capitano, A. Upadhyaya, P. Kurzawski, K. E. Wack, D. Beer Stolz, R. Kamm, L. G. Griffith, A Microfabricated Array Bioreactor for Perfused 3D Liver Culture, Biotechnology and Bioengineering, 2002, 78, 257-269. [pdf]

• S. Baskaran, J. Liu, K. Domansky, X. Li, N. Kohler, G. Fryxell, S. Thevuthasan, and R. E. Williford, Low Dielectric Constant Mesoporous Silica Films through Molecularly Templated Synthesis, Advanced Materials, 2000, 12, 291-294. [pdf]

• K. Domansky, A. Rose, W. H. Grover, and G. J. Exarhos, Localized Deposition of Zinc Oxide Films by Automated Fluid Dispensing Method, Materials Science & Engineering, B76, 2000, 116-121. [pdf]

• K. Domansky, D. L. Baldwin, J. W. Grate, T. B. Hall, J. Li, M. Josowicz, and J. Janata, Development and Calibration of Field-Effect Transistor-Based Sensor Array for Measurement of Hydrogen and Ammonia Gas Mixtures in Humid Air, Analytical Chemistry, 1998, 70, 473-481. [pdf]

• K. Domansky, Y. Leng, C. C. Williams, J. Janata and D. Petelenz, Mapping of Mobile Charges on Insulator Surfaces with the Electrostatic Force Microscope, Applied Physics Letters, 1993, 63, 1513-1515. [pdf]

• K. Domansky, J. Janata, M. Josowicz, and D. Petelenz, Present State of Fabrication of Chemically Sensitive Field Effect Transistors, Analyst, 1993, 118, 335-340. [pdf]

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